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M9630328.TXT
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1996-02-27
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2KB
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29 lines
Document 0328
DOCN M9630328
TI Is Kaposi's-sarcoma-associated herpesvirus detectable in semen of
HIV-infected homosexual men?
DT 9603
AU Lin JC; Lin SC; Mar EC; Pellett PE; Stamey FR; Stewart JA; Spira TJ;
Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.
SO Lancet. 1995 Dec 16;346(8990):1601-2. Unique Identifier : AIDSLINE
MED/96106230
AB We explored a possible route of transmission of
Kaposi's-sarcoma-associated herpes virus (KSHV) with nested and unnested
PCR techniques. We looked for KSHV DNA sequences in semen of
HIV-positive homosexual men and HIV-negative healthy semen donors. With
unnested primers we found KSHV sequences in 21 of 33 (64%) homosexual
men and in none of 30 healthy donors. With a nested PCR assay, 30 of 33
(91%) specimens from the homosexual men and 7 of 30 (23%) specimens from
healthy donors had detectable KSHV sequences. Over 5 years of follow-up,
13 of 30 KSHV-positive homosexual men (43%) developed KS compared with
none of the 3 KSHV-negative homosexual men.
DE DNA, Viral/GENETICS Herpesviridae/GENETICS/*ISOLATION & PURIF
*Homosexuality, Male Human HIV Infections/*COMPLICATIONS/VIROLOGY HIV
Seronegativity Male Polymerase Chain Reaction Retrospective Studies
Sarcoma, Kaposi's/ETIOLOGY/*VIROLOGY Semen/*VIROLOGY Sequence
Analysis, DNA JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).